Yeast proteins, PROST analysis

PROST analysis of orphan Saccharomyces cerevisiae genes, searched against seven out-of-phylum species — E. gossypii, K. lactis, N. castellii, L. waltii, Y. lipolytica, A. nidulans, S. pombe — four of which (E. gossypii, K. lactis, N. castellii, L. waltii) have synteny information in the Yeast Gene Order Browser.

126 yeast genes are predicted to evolve fast [1] and so may not be detectable in out-of-phylum species. PROST found homologs for 92 of those 126, where a synteny-based BLAST search found homologs for only 11 (Table S2). For the 29 genes in Table S3 the lineage specificity is not explained by rate of evolution; there PROST finds homologs in 21 cases against BLAST's 12.

• Name — the orphan protein; follow the link for a detail page.
• Pdetection — from [1]; below 0.95 means the protein evolves too fast for traditional sequence-similarity tools.
• Best homolog — the homolog with the most significant FATCAT [2] structural alignment.
• Weisman homolog — found by BLAST against synteny proteins only [1].
• Total PROST hom. — homologs PROST found across the seven species.
• Non-sig. struc. hom. — homologs without significant structural similarity to the query.
• Found synteny hom. — synteny homologs PROST recovered.
• Total synteny hom. — synteny homologs the query has in the four YGOB species; at most 4.

Table S2 — S. cerevisiae lineage-specific (Pdet < 0.95) proteins

Table S3 — S. cerevisiae non-lineage-specific (Pdet ≥ 0.95) proteins